Innovative science

We have applied our insights into the structure and biological function of individual PI3K and HDAC enzymes to de novo-design and develop innovative new cancer drugs with significant clinical potential. Our PI3K-p110β/δ-selective inhibitor, KA2237, is in Phase I in patients with B-cell lymphoma. Our selective HDAC6 inhibitor, KA2507, is entering Phase I trials in patients with solid tumors.

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Clinical pipeline

We are collaborating with The University of Texas MD Anderson Cancer Center, which is conducting the Phase I clinical trials for KA2237 and KA2507 in patients with B-cell lymphoma and PD-L1-expressing solid tumors, respectively.

KA2237 – Phase I

KA2237 is a potent, dual-selective inhibitor of the p110β and p110δ isoforms of PI3K. This drug has a combined targeted and immunotherapeutic mode of action. It inhibits oncogenic pathways within cancer cells, and drives immunotherapeutic activity within the tumor microenvironment. Its selectivity for p110β and p110δ reduces the potential for side effects connected to p110α and p110γ inhibition.

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KA2507 – Phase I

KA2507 is a potent and selective inhibitor of HDAC6. Selective HDAC6 inhibition promotes tumor cell apoptosis by suppressing aggresome formation and also drives immunotherapeutic inhibition of cancer cell proliferation by modulating key tumor microenvironment markers, including by downregulating the expression of programmed death ligand-1 (PD-L1).

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Press Releases

 
  • 18 September 2017
    Karus Therapeutics Announces First Cancer Patients Dosed with KA2507, a Small Molecule HDAC6-Selective Inhibitor, in a Phase I Clinical Trial
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  • 04 August 2017
    Karus Therapeutics presenting at the CHI DoT 11th Annual Next-Generation Histone Deacetylase Inhibitors conference
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  • 01 May 2017
    Karus Therapeutics presenting at the 18th Annual Drug Discovery Summit/5th Annual Discovery Chemistry & Drug Design
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In The News

 
  • 04 November 2016
    Karus Therapeutics features in BioCentury Innovations
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  • 15 May 2014
    Karus Therapeutics features in SciBX
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  • 25 February 2014
    Karus Therapeutics showcased in BVCA’s Britain’s Hot Talents 2014/15
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